Deborah Brian appeared in three roles in Coronation Street:
- A Nursing Sister based at Victoria Hospital, Blackpool in November 2003
- A Practice Nurse at Rosamund Street Medical Centre who treated Amy Barlow for a suspected milk allergy in May 2011
- A Social Worker who met Tyrone Dobbs at the Cragg Street Children's Contact Centre for a supervised visit to see his daughter Ruby Soames in February 2013 and returned in June 2017 over Bethany Platt being groomed by Nathan Curtis
She is known for her roles in The Spell, The Jumper, and Blue Murder.